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An improved method for the chemical synthesis of steroidal 20-oxo-21-oic acids
Steroids
|November 1, 1983
Abstract:
A procedure is described for the chemical synthesis of steroidal-20-oxo-21-oic acids and -17 alpha(-hydroxy-20-oxo-21-oic acids. Corticosteroid derivatives containing the 20-oxo-21-aldehyde side chain are oxidized with freshly generated silver oxide in dilute aqueous sodium hydroxide.