Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methotrexate levels, a guide to therapy?

J Edelman, A S Russell, D F Biggs

    Clinical and Experimental Rheumatology
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Appeals to environmental protection and farmer adoption of sustainable natural resource management - A case study of Kaya, Burkina Faso.

    Journal of environmental management·2025
    Same author

    Glycerine in Veterinary Practice.

    The Journal of comparative medicine and veterinary archives·2022
    Same author

    Correction to: PANLAR consensus statement on biosimilars.

    Clinical rheumatology·2019
    Same author

    PANLAR consensus statement on biosimilars.

    Clinical rheumatology·2019
    Same author

    Hot joints: myth or reality? A thermographic joint assessment of inflammatory arthritis patients.

    Clinical rheumatology·2018
    Same author

    The threat of litigation as a possible barrier to innovation.

    Internal medicine journal·2016
    Same journal

    The expanded cardiovascular risk prediction score as a cardiovascular mortality predictor in rheumatoid arthritis.

    Clinical and experimental rheumatology·2026
    Same journal

    Rising overweight and obesity in Swiss psoriatic arthritis patients, 2007-2022: a nationwide registry-population comparison.

    Clinical and experimental rheumatology·2026
    Same journal

    Clinical features and gastrointestinal bleeding risk factors in IgA vasculitis patients: a retrospective study in a large volume centre.

    Clinical and experimental rheumatology·2026
    Same journal

    Reply to the comment on: The microbiota in axial spondyloarthritis: what have we learned from Mendelian randomisation studies?

    Clinical and experimental rheumatology·2026
    Same journal

    Comprehensive evaluation of bone structural and microarchitectural changes in rheumatoid arthritis treated with baricitinib using HR-pQCT, imaging, and biomarker analyses.

    Clinical and experimental rheumatology·2026
    Same journal

    Tracking interstitial lung disease in systemic sclerosis: integrating lung magnetic resonance imaging into a clinically oriented multimodal follow-up strategy.

    Clinical and experimental rheumatology·2026
    See all related articles

    Methotrexate (MTX) effectively treats inflammatory arthritis in most patients. Monitoring 24-hour serum MTX levels helps identify toxicity risks, supporting optimal 10 mg intramuscular dosing.

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Methotrexate (MTX) is increasingly utilized for inflammatory arthritis management.
    • A significant majority of patients tolerate MTX treatment, with low discontinuation rates due to toxicity.

    Purpose of the Study:

    • To evaluate the optimal intramuscular dosage of Methotrexate for treating inflammatory arthritis.
    • To establish serum level thresholds for predicting Methotrexate toxicity.

    Main Methods:

    • A cohort of seventy-one patients with inflammatory arthritis receiving Methotrexate treatment was studied.
    • Serum Methotrexate levels were measured at 24 hours post-administration following a 10 mg intramuscular dose.

    Main Results:

    Related Experiment Videos

  • Only five out of seventy-one patients discontinued Methotrexate due to toxicity.
  • A 24-hour serum Methotrexate level below 0.01 mumole/litre was observed in patients tolerating the 10 mg intramuscular dose.

    • Conclusions:

    • Intramuscular Methotrexate at 10 mg once weekly appears to be an optimal regimen for inflammatory arthritis.
    • Monitoring 24-hour serum Methotrexate levels can help identify patients at higher risk of adverse effects.