Reactions induced by the concurrent use of thimerosal and tetracycline
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Updated: Sep 12, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Abstract:
We examined the reaction to thimerosal which occurred when patients were prescribed tetracyclines simultaneously. Nine patients were identified who had been using a 0.004% thimerosal-containing contact lens solution for over 6 months. All had developed varying degrees of ocular reaction (red eye, irritation, blepharitis) apparently as a result of taking tetracyclines concurrently. The reaction disappeared upon discontinuance of either the thimerosal or the tetracyclines. The hypothesis that the reaction was due to an interaction between thimerosal and tetracyclines was confirmed in rabbits.
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