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Myocardial dysfunction in hypothyroid children.

Z Q Farooki, W H Hoffman, B L Perry

    American Journal of Diseases of Children (1960)
    |January 1, 1983
    PubMed
    Summary
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    Pediatric hypothyroidism can cause heart problems like pericardial effusion and abnormal myocardial function. Treatment with hormone replacement therapy effectively reversed these cardiac issues in children.

    Area of Science:

    • Pediatric Cardiology
    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • Primary hypothyroidism in children can affect multiple organ systems.
    • Cardiac involvement is a known complication of hypothyroidism in adults.
    • The impact of childhood hypothyroidism on cardiac structure and function requires further elucidation.

    Purpose of the Study:

    • To investigate the cardiac manifestations of primary hypothyroidism in children.
    • To assess the reversibility of these cardiac abnormalities following treatment.
    • To compare the cardiac response in children with hypothyroidism to that observed in adults.

    Main Methods:

    • Echocardiography was utilized to evaluate cardiac structure and function.
    • Systolic time intervals were analyzed to assess myocardial performance.

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  • Cardiac measurements included pericardial effusion assessment and septal hypertrophy evaluation.

    • Main Results:

    • Eight out of eleven children with hypothyroidism presented with pericardial effusion.
    • Abnormal myocardial function was suggested by altered systolic time intervals.
    • Two children exhibited asymmetric septal hypertrophy without outflow obstruction.
    • All cardiac abnormalities resolved after complete hormone replacement therapy.

    Conclusions:

    • Childhood hypothyroidism is associated with significant myopericardial abnormalities.
    • These cardiac changes are reversible with appropriate thyroid hormone replacement.
    • The cardiac effects of hypothyroidism in children mirror those seen in adult populations.