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Decrease in mitogen responsiveness of mononuclear cells from peripheral blood after epinephrine administration in

B Crary, M Borysenko, D C Sutherland

    Journal of Immunology (Baltimore, Md. : 1950)
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Epinephrine injection temporarily reduces the immune response of mononuclear cells (MNC) to mitogens like PWM and PHA. This effect, observed in healthy subjects, is linked to shifts in lymphocyte distribution, not cell viability.

    Area of Science:

    • Immunology
    • Endocrinology
    • Cell Biology

    Background:

    • Epinephrine, a stress hormone, influences various physiological processes.
    • Previous research suggests epinephrine affects circulating lymphocyte populations.

    Purpose of the Study:

    • To investigate the impact of epinephrine administration on human peripheral blood mononuclear cell (MNC) function.
    • To determine if epinephrine affects the mitogenic response of lymphocytes.

    Main Methods:

    • Healthy subjects received a single subcutaneous injection of epinephrine.
    • Mononuclear cells (MNC) were isolated at various time points post-injection.
    • MNC were cultured with mitogens (PWM, PHA, Con A) to assess blastogenic response.

    Main Results:

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    • Epinephrine caused a transient lymphocytosis.
    • Mitogenic responses of MNC to PWM and PHA were significantly reduced for up to 60 minutes post-injection.
    • Con A response was reduced only at 15 minutes; all responses normalized by 120 minutes.
    • Epinephrine did not affect MNC viability or in vitro mitogen responsiveness.

    Conclusions:

    • The transient reduction in mitogen responsiveness after epinephrine is likely due to altered lymphocyte subset distribution.
    • Epinephrine's effects on immune cell function are temporary and related to redistribution rather than direct cellular toxicity.