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Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
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Published on: December 18, 2010

Treatment of Torulopsis glabrata peritonitis with intraperitoneal amphotericin B

P S Rahko, W P Davey, L J Wheat

    JAMA
    |March 4, 1983
    PubMed

    Insights

    Torulopsis glabrata peritonitis, a rare fungal infection, was successfully treated with intraperitoneal amphotericin B. This case highlights effective treatment for T glabrata and Candida peritonitis.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Surgical Infections

    Background:

    • Peritonitis can arise post-surgery, particularly after abdominal viscus rupture.
    • Fungal peritonitis, though less common, poses a significant clinical challenge.
    • Torulopsis glabrata (Candida glabrata) is an opportunistic fungal pathogen.

    Observation:

    • A patient developed Torulopsis glabrata peritonitis following surgery for a ruptured abdominal viscus.
    • The infection was localized and confined to the peritoneal cavity.

    Findings:

    • Intraperitoneal administration of amphotericin B alone achieved successful treatment.
    • Pharmacokinetic data on peritoneal amphotericin B distribution and clearance were obtained.
    • Clinical features and treatment options for T glabrata and Candida peritonitis were reviewed.

    Implications:

    • Intraperitoneal amphotericin B is a viable therapeutic option for Torulopsis glabrata peritonitis.
    • Understanding pharmacokinetics is crucial for optimizing antifungal therapy via intraperitoneal route.
    • This case contributes to the management strategies for fungal peritonitis in surgical patients.

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