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Folate turnover in chronically alcoholic monkeys.

T Tamura, C H Halsted

    The Journal of Laboratory and Clinical Medicine
    |April 1, 1983
    PubMed
    Summary
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    Chronic alcoholism increases folate loss through urine and feces, leading to deficiency. This study in monkeys shows higher excretion and lower liver folate levels in alcohol-fed subjects.

    Area of Science:

    • Nutritional Science
    • Gastroenterology
    • Toxicology

    Background:

    • Chronic alcoholism is associated with folate deficiency.
    • The precise mechanisms underlying this deficiency remain incompletely understood.

    Purpose of the Study:

    • To investigate the pathogenesis of folate deficiency in chronic alcoholism.
    • To determine the impact of chronic ethanol consumption on folate metabolism and excretion.

    Main Methods:

    • Monkeys were administered liquid diets with 50% energy from ethanol for 4 years.
    • Tracer doses of 3H-folic acid were administered, and excretion and turnover were measured over 25 days.
    • Liver folate levels and tritium recovery were assessed at autopsy.

    Main Results:

    Related Experiment Videos

    • Ethanol-fed monkeys showed significantly greater urinary and fecal excretion of tritium within the first 3 days.
    • A rapid elimination phase of tritium was observed, with a shorter half-time in ethanol-fed monkeys.
    • Decreased hepatic folate levels and tritium recovery were noted in alcohol-fed monkeys at autopsy.

    Conclusions:

    • Folate deficiency in chronic alcoholism is partly due to increased urinary and fecal losses.
    • Ethanol consumption leads to decreased hepatic incorporation of exogenous folate.
    • Long-term folate turnover appears unaffected by chronic ethanol intake.