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Structural similarities and differences amongst neurofilaments.

C Wais-Steider, P A Eagles, D S Gilbert

    Journal of Molecular Biology
    |April 5, 1983
    PubMed
    Summary
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    Neurofilaments from various species share a common coiled-coil structure, despite differences in polypeptide composition and diameter. X-ray diffraction reveals this conserved alpha-helical arrangement in nerve fibers.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Structural Biology

    Background:

    • Neurofilaments are key components of nerve fibers, providing structural support and influencing axonal transport.
    • Variations exist in neurofilament composition and diameter across different species, including mammals and marine invertebrates.

    Purpose of the Study:

    • To investigate the structural similarities and differences of neurofilaments from diverse sources.
    • To determine the common structural elements present in neurofilaments despite compositional variations.

    Main Methods:

    • Purification of neurofilaments from mammalian (cat, ox) and marine invertebrate (Loligo, Myxicola) nerve fibers.
    • Analysis of neurofilament structure using X-ray diffraction techniques.

    Main Results:

    Related Experiment Videos

    • Neurofilaments from different species exhibit varying numbers of polypeptides and molecular weights.
    • Mammalian neurofilaments are approximately 20% larger in diameter than those from marine invertebrates.
    • X-ray diffraction patterns reveal a conserved alpha-helical content, arranged in coiled-coils, across all examined neurofilaments.
    • Specific long-range periodicity (25.2 nm) was observed in Myxicola neurofilaments.

    Conclusions:

    • Despite compositional and diameter differences, neurofilaments share a fundamental coiled-coil alpha-helical structure.
    • This conserved structure suggests a common functional role or evolutionary origin for neurofilaments across diverse organisms.