Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myopathy and hypersensitivity to phenytoin.

J Harney, M R Glasberg

    Neurology
    |June 1, 1983
    PubMed
    Summary

    Phenytoin hypersensitivity can cause severe myopathy, hepatitis, and muscle weakness in patients with seizure disorders. Alternative anticonvulsants are recommended for individuals with immune system abnormalities.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    External Validation of the Royal Marsden Hospital Stereotactic Radiosurgery Survival Score for Patients With Brain Metastases Treated With Stereotactic Radiosurgery.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2025
    Same author

    Risk of Death from Pneumocystis jirovecii after Curative-intent Radiotherapy for Lung Cancer.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2018
    Same author

    The Impact of Colleague Peer Review on the Radiotherapy Treatment Planning Process in the Radical Treatment of Lung Cancer.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2015
    Same author

    Primary adenoid cystic carcinoma of the bronchus in a female teenager.

    BMJ case reports·2012
    Same author

    Re-irradiation of recurrent medulloblastoma--a case report.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2008
    Same author

    Cancer chemotherapy administered via hemodialysis fistulas.

    The journal of vascular access·2006

    Area of Science:

    • Neurology
    • Toxicology
    • Immunology

    Background:

    • Generalized seizure disorder is a common neurological condition.
    • Phenytoin is a frequently prescribed anticonvulsant medication.
    • Hypersensitivity reactions to medications can manifest in various ways.

    Observation:

    • A 19-year-old male patient with generalized seizures was treated with phenytoin.
    • The patient developed a hypersensitivity reaction including hepatitis, severe myalgia, and proximal arm weakness.
    • Elevated serum creatine kinase levels were noted.

    Findings:

    • Muscle biopsy confirmed the presence of myopathy.
    • The observed symptoms were indicative of a severe phenytoin-induced hypersensitivity reaction.
    • Immune system abnormalities may predispose patients to such reactions.

    Implications:

    • Patients with seizure disorders experiencing hypersensitivity reactions require careful management.
    • Alternative anticonvulsant therapies should be considered for patients with abnormal immune responsiveness.
    • This case highlights the importance of monitoring for adverse drug reactions, particularly myopathy and hepatitis, during phenytoin treatment.

    Related Experiment Videos