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[11-Desoxycorticosterone * (DOC) during pregnancy and labor]
Zeitschrift Fur Geburtshilfe Und Perinatologie
|January 1, 1983
Summary
This study investigated changes in dehydroepiandrosterone sulfate (DS) during pregnancy. DS levels are higher in umbilical cord blood than maternal blood, decreasing rapidly after birth in both mother and infant.
Area of Science:
- Endocrinology
- Reproductive Biology
- Perinatal Medicine
Background:
- Dehydroepiandrosterone sulfate (DS) is a key steroid hormone during pregnancy.
- Maternal and fetal steroid levels undergo significant changes throughout gestation and postpartum.
Purpose of the Study:
- To investigate the concentration changes of dehydroepiandrosterone sulfate (DS) during pregnancy.
- To compare DS levels in maternal blood, umbilical cord blood, and postpartum samples.
Main Methods:
- Blood samples were collected from mothers and umbilical cords at the 8th and 40th weeks of gestation.
- Hormone concentrations were measured using established laboratory techniques.
Main Results:
- Dehydroepiandrosterone sulfate (DS) concentrations increased during pregnancy.
- Sub partu, umbilical cord blood exhibited higher DS levels compared to maternal blood.
- A rapid decline in DS levels was observed postpartum in both mothers and infants.
Conclusions:
- The fetoplacental unit is implicated as a potential site for steroid synthesis.
- Postpartum hormonal shifts highlight the transition from fetal to neonatal endocrine regulation.