[Effect of doxycycline and isoconazole nitrate on human intestinal fungal flora]

29 patients from an outpatient department for pulmonary diseases were treated in randomized order with both doxycycline alone and in combination with 1-(2,4-dichloro-beta-(2,6-dichlorobenzyloxy)-phenethyl)-imidazole nitrate (isoconazole nitrate, Gyno-Travogen) 300 mg/day as well as 600 mg/day for 14 days. In 15 of the 29 patients, it was possible to detect Candida albicans in the stool before the beginning of therapy 10 patients being on a cortisone therapy with an average duration of 32.9 months. Under doxycycline monotherapy, a proliferation of the human intestinal flora by yeast-spp. did not occur. Furthermore, it was not possible to detect an effect of isoconazole nitrate on the human fecal intestinal flora.