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Related Experiment Videos

Increased androgen binding in keloids: a preliminary communication.

L C Ford, D F King, L D Lagasse

    The Journal of Dermatologic Surgery and Oncology
    |July 1, 1983
    PubMed
    Summary
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    Keloids show significantly higher androgen binding compared to normal skin and simple scars. This suggests that increased androgen metabolism may contribute to keloid formation.

    Area of Science:

    • Dermatology
    • Endocrinology
    • Biochemistry

    Background:

    • Keloids are abnormal scars characterized by excessive collagen deposition.
    • The role of sex hormones in keloid pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the levels of sex hormone binding proteins in keloids compared to adjacent skin and simple scars.
    • To explore the potential role of androgen metabolism in keloid development.

    Main Methods:

    • Sex hormone binding protein (SHBP) analyses were conducted on keloid tissue, adjacent skin, and simple scar tissue.
    • Quantification of androgen, estrogen, and progesterone binding activities in cytosol protein extracts.

    Main Results:

    • Keloid tissues exhibited significantly higher androgen binding (510–1149 Fm/mg cytosol protein) compared to adjacent skin (177–476 Fm/mg) and simple scars (<60 Fm/mg).

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  • Estrogen and progesterone binding activities were low in all tissue types, with near-undetectable levels in simple scars.

    • Conclusions:

    • Localized hyperandrogen metabolism is implicated as a potential causal or contributory factor in the pathogenesis of keloids.
    • These findings highlight a specific hormonal imbalance that may drive keloid formation.