Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental studies on amniotic fluid embolism].

Y Sakurai

    Nihon Sanka Fujinka Gakkai Zasshi
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Meconium and bile, not amniotic fluid, trigger shock symptoms in experimental amniotic fluid embolism (AFE) models. Pulmonary vasoconstriction, caused by amniotic fluid

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Novel sensing system for glucose based on the complex formation between phenylborate and fluorescent diol compounds.

    Journal of biochemistry·1995
    Same author

    Temperature-modulated platelet and lymphocyte interactions with poly(N-isopropylacrylamide)-grafted surfaces.

    Biomaterials·1995
    Same author

    The failure of retrograde continuous warm-blood cardioplegia to resuscitate cardiac function in experimental acute coronary artery occlusion and reperfusion.

    The Thoracic and cardiovascular surgeon·1995
    Same author

    Gallstone disease among Japanese men in relation to obesity, glucose intolerance, exercise, alcohol use, and smoking.

    Scandinavian journal of gastroenterology·1995
    Same author

    Hypofrontality does not occur with 6-hydroxydopamine lesions of the medial prefrontal cortex in rat brain.

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·1995
    Same author

    Cytoplasmic calcium level and membrane fluidity of platelets contacting poly(acrylamide-co-methacrylic acid) particles with different surface properties.

    Journal of biomaterials science. Polymer edition·1995

    Area of Science:

    • Cardiovascular Physiology
    • Obstetric Emergencies
    • Pulmonary Hemodynamics

    Context:

    • Amniotic fluid embolism (AFE) is a rare but catastrophic obstetric emergency.
    • The precise pathophysiology of AFE, particularly the causative agents, remains incompletely understood.
    • Previous experimental models have yielded variable results in replicating AFE's shock state.

    Purpose:

    • To investigate the circulatory effects of various amniotic fluid components and related substances in an experimental canine model.
    • To differentiate the shock-inducing potential of meconium-stained amniotic fluid, meconium, and bile compared to clear amniotic fluid.
    • To elucidate the primary mechanisms underlying the shock symptoms observed in experimental amniotic fluid embolism.

    Summary:

    • Infusion of meconium-stained amniotic fluid, meconium suspension, or canine bile induced typical shock symptoms in dogs, unlike clear amniotic fluid.

    Related Experiment Videos

  • Shock was characterized by rapid arterial pressure decrease, increased right ventricular and pulmonary arterial pressures, elevated pulmonary vascular resistance, decreased cardiac output, and sudden central venous pressure increases.
  • Pulmonary vasoconstriction, mediated by amniotic fluid's chemical factors and vasoactive substances from the lung, was identified as the likely primary cause of AFE shock, rather than mechanical obstruction.

    • Impact:

    • Provides critical insights into the etiological agents responsible for amniotic fluid embolism shock.
    • Highlights the role of pulmonary vasoconstriction as the key pathophysiological mechanism in AFE.
    • Informs future research directions for understanding and potentially managing this critical obstetric condition.