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What is elastin; what is not.

D W Urry

    Ultrastructural Pathology
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Fibrous elastin, a complex biologic material, is described as ordered filaments, not a random network. This perspective, supported by structural and thermodynamic data, proposes a new mechanism for elasticity.

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    Area of Science:

    • Biophysics
    • Materials Science
    • Molecular Biology

    Background:

    • Elastin's structure is debated: random network vs. ordered filaments.
    • Previous models often analogized elastin to rubber elasticity.
    • Biologic materials previously considered disordered are increasingly understood to have regular structures.

    Purpose of the Study:

    • To review and present the perspective of elastin as ordered filaments.
    • To propose a new mechanism of elasticity based on molecular conformation.
    • To provide a basis for understanding elastin's molecular pathology.

    Main Methods:

    • Analysis of primary structure and cross-links of elastin.
    • Review of electron microscopy studies on fibrous elastin and elastin peptides.

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  • Conformational analysis of elastin peptides.

    • Main Results:

    • Elastin's primary structure and cross-links support an ordered filament model.
    • Electron microscopy reveals filaments consistent with conformational descriptions.
    • A three-component model for elastin's fundamental unit is proposed.
    • Conformations are consistent with thermodynamic, birefringence, and chain mobility data.

    Conclusions:

    • Elastin is best described as ordered filaments with preferred conformations.
    • The librational entropy mechanism of elasticity is proposed.
    • Understanding molecular conformation is key to elastin's molecular pathology.