Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pregnancy and hyperprolactinemia].

G Hoffmann, R H Ackermann, J Happ

    Experimental and Clinical Endocrinology
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Combined IMIG and immune Ig attenuates inflammatory colitis in mice.

    International immunopharmacology·2020
    Same author

    Opinion paper: Measuring livestock robustness and resilience: are we on the right track?

    Animal : an international journal of animal bioscience·2020
    Same author

    Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network.

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2019
    Same author

    Technical note: Development of a noninvasive respiration rate sensor for cattle.

    Journal of dairy science·2018
    Same author

    BRCA1-like profile is not significantly associated with survival benefit of non-myeloablative intensified chemotherapy in the GAIN randomized controlled trial.

    Breast cancer research and treatment·2017
    Same author

    [Safe treatment of acute hyperkalemia : The 1:4 and other principles].

    Der Anaesthesist·2017
    Same journal

    Autoantibodies to glutamate decarboxylase detected in diabetes-prone BB/OK rats do not distinguish onset of diabetes.

    Experimental and clinical endocrinology·1994
    Same journal

    Urinary excretion of hydroxy-pyridinium cross-links of collagen reflects skeletal growth velocity in normal children.

    Experimental and clinical endocrinology·1994
    Same journal

    Tissue regenerates of adrenal cortex with a physiological function twelve years after bilateral total adrenalectomy for Cushing's syndrome.

    Experimental and clinical endocrinology·1994
    Same journal

    Thyroid hormone deiodination in target tissues--a regulatory role for the trace element selenium?

    Experimental and clinical endocrinology·1994
    Same journal

    Effects of music treatment on salivary cortisol in patients exposed to pre-surgical stress.

    Experimental and clinical endocrinology·1994
    Same journal

    Systolic ventricular function in acute hypothyroidism: a study using Doppler echocardiography.

    Experimental and clinical endocrinology·1994
    See all related articles

    Bromocriptine therapy enabled 13 hyperprolactinemia patients to conceive. Pregnancies were generally uncomplicated, with no fetal malformations observed, indicating successful management of prolactin-secreting adenomas.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Neurosurgery

    Background:

    • Hyperprolactinemia is a common endocrine disorder often associated with pituitary adenomas.
    • Elevated prolactin levels can impair fertility and necessitate treatment for conception.

    Purpose of the Study:

    • To evaluate the safety and efficacy of bromocriptine therapy in achieving pregnancy in patients with hyperprolactinemia.
    • To assess pregnancy outcomes and potential complications in patients with prolactin-secreting adenomas managed with bromocriptine.

    Main Methods:

    • Endocrinological and radiological assessments were performed on 13 patients with hyperprolactinemia.
    • Bromocriptine therapy was administered to facilitate pregnancy.
    • Surgical intervention (selective adenomectomy) was performed in two patients.

    Related Experiment Videos

  • Serial monitoring of serum prolactin (PRL) levels, radiological imaging, and visual field assessments were conducted.

    • Main Results:

    • Thirteen patients successfully conceived under bromocriptine therapy.
    • Twelve pregnancies were uncomplicated, with serum PRL levels mostly within the normal range.
    • No tumor recurrence was observed in patients monitored for rapid PRL level increases.
    • One patient with a microadenoma experienced a sudden chiasma syndrome due to hemorrhage into the adenoma, which resolved post-operatively.
    • No fetal malformations were noted, and postpartum sella X-rays showed no significant changes.

    Conclusions:

    • Bromocriptine therapy is an effective treatment for inducing pregnancy in women with hyperprolactinemia.
    • Pregnancies in this cohort were generally safe, with a low incidence of complications.
    • Careful monitoring is essential, as pituitary adenomas can present with acute complications like hemorrhage during gestation.