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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Cerebrospinal fluid trace element content in dementia: clinical, radiologic, and pathologic correlations
Neurology
|October 1, 1983
Summary
Elevated silicon levels in cerebrospinal fluid (CSF) were found in patients with Alzheimer-type dementia (ATD) and Alzheimer
Area of Science:
- Neurology
- Biochemistry
- Analytical Chemistry
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- Trace element dysregulation in cerebrospinal fluid (CSF) is implicated in neurodegeneration.
- Diagnostic biomarkers for AD are crucial for early intervention.
Purpose of the Study:
- To investigate the association between specific trace elements in CSF and Alzheimer-type dementia (ATD) and other dementing illnesses.
- To determine if silicon, aluminum, arsenic, lead, or manganese levels differ in patients with neurological conditions compared to controls.
Main Methods:
- Inductively coupled argon plasma emission spectroscopy was used to measure 19 trace elements in CSF.
- CSF samples were analyzed from 265 patients, including those with ATD, other dementias, and no neurologic disease.
- Autopsy-proven Alzheimer's disease (AD) cases and autopsy controls were included for comparison.
Main Results:
- Elevated CSF silicon levels were observed in 24% of ATD patients and 71% of AD patients.
- No significant relationship was found between CSF levels of aluminum, arsenic, lead, or manganese and ATD, AD, or other dementing illnesses.
- Silicon emerged as a potential biomarker differentiating AD patients from controls.
Conclusions:
- CSF silicon levels may serve as a potential biomarker for Alzheimer's disease.
- Further research is warranted to explore the role of silicon in AD pathogenesis.
- The study did not find correlations between CSF aluminum, arsenic, lead, or manganese and dementia.
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CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
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