The effect of strenuous exercise on the reactivity of the central dopaminergic system in the rat

In rats subjected to physical strain the action of dopamine receptor agonists, amphetamine and apomorphine, was enhanced, but the effects of an antagonist, haloperidol, remained unchanged. The levels of biogenic amines in several brain regions were changed after the exercise. The results indicate that physical strain changes the functions of the central dopaminergic system in the rat.