[Nalidixic acid: urinary levels during short-term therapy with reduced doses]

Area of Science:

• Urology
• Infectious Diseases
• Pharmacology

Context:

• Acute lower urinary tract infections are superficial mucosal infections.
• Exclusion of structural and functional anomalies is crucial for diagnosis.
• Antibacterial agents with high urine concentrations can effectively treat infections.

Purpose:

• To investigate the urinary concentration of biologically active metabolites of nalidixic acid.
• To determine if these concentrations exceed minimum inhibitory concentrations (MICs) in the urinary tract.
• To correlate results from fluorimetric and microbiological assays.

Summary:

• Administration of 2 g daily dose of nalidixic acid resulted in urinary metabolite concentrations exceeding MICs.
• Both fluorimetric and microbiological methods confirmed the presence of active substances.
• The study demonstrated a good correlation between the two analytical methods.

Impact:

• Confirms nalidixic acid's efficacy in treating uncomplicated lower urinary tract infections.
• Provides evidence for optimal dosing strategies based on urinary metabolite concentrations.
• Highlights the reliability of combined analytical methods for drug monitoring.