Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pituitary-thyroid function during acute immobilization stress in rats.

P Langer, O Földes, R Kvetnanský

    Experimental and Clinical Endocrinology
    |July 1, 1983
    PubMed
    Summary

    Immobilization stress in rats initially alters thyroid hormones, with levels returning to normal after a day of rest. This study investigates the impact of immobilization stress on thyroid hormone regulation in male Wistar rats.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [A rare subtype of duodenal neuroendocrine tumors].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2021
    Same author

    Surgical therapy of adrenal tumors: guidelines from the German Association of Endocrine Surgeons (CAEK).

    Langenbeck's archives of surgery·2019
    Same author

    Respiratory-induced hemodynamic changes measured by whole-body multichannel impedance plethysmography.

    Physiological research·2018
    Same author

    Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPARγ - dependent mechanism.

    Neoplasma·2017
    Same author

    <i>In vitro</i> evaluation of aliphatic fatty alcohol metabolites of <i>Perseaamericana</i> seed as potential antimalarial and antimicrobial agents.

    Nigerian journal of biotechnology·2017
    Same author

    Refinement of screening for familial pancreatic cancer.

    Gut·2016

    Area of Science:

    • Endocrinology
    • Stress Physiology
    • Animal Models

    Background:

    • Thyroid hormones, including thyrotropin (TSH), thyroxine (T4), triiodothyronine (T3), and reverse triiodothyronine (rT3), play crucial roles in regulating metabolism and physiological responses.
    • Immobilization stress is a known physiological stressor that can impact various endocrine systems.

    Purpose of the Study:

    • To investigate the acute and chronic effects of immobilization stress on plasma levels of TSH, T4, T3, and rT3 in male Wistar rats.
    • To determine the time course of thyroid hormone alterations following immobilization stress.
    • To assess the reversibility of these hormonal changes after a period of recovery.

    Main Methods:

    • Nine experiments were conducted using a total of 394 male Wistar rats.

    Related Experiment Videos

  • Animals were subjected to immobilization stress for varying durations (2 to 240 minutes) in a prone position.
  • Plasma levels of TSH, T4, T3, and rT3 were measured using radioimmunoassay following decapitation.

    • Main Results:

    • Acute immobilization (2-15 min) caused initial increases in TSH, T4, and rT3, with a decrease in T3.
    • Prolonged immobilization (30-240 min) led to significant decreases in TSH, T4, and T3 levels compared to controls.
    • Repeated daily immobilization induced similar hormonal changes, which normalized after one day of rest.

    Conclusions:

    • Immobilization stress significantly alters thyroid hormone profiles in rats, with distinct initial and prolonged effects.
    • The observed changes in thyroid hormone levels are reversible, with a single day of rest being sufficient for recovery.
    • These findings highlight the sensitivity of the thyroid axis to immobilization stress and its capacity for adaptation.