Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Citrinin mycotoxicosis in the rabbit.

C Hanika, W W Carlton, J Tuite

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |August 1, 1983
    PubMed
    Summary

    Citrinin toxicity in rabbits shows a 72-hr LD50 of 50 mg/kg (intraperitoneal) and 134 mg/kg (oral). Kidney damage, including tubular necrosis and regeneration, was observed following citrinin exposure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lockjaw syndrome in cockatiels associated with sinusitis.

    Avian pathology : journal of the W.V.P.A·2009
    Same author

    Assessment of the morphology and significance of the lymph nodal and hepatic lesions produced in rats by the feeding of certain mineral oils and waxes. Proceedings of a pathology workshop held at the Fraunhofer Institute of Toxicology and Aerosol Research Hannover, Germany, May 7-9, 2001.

    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie·2001
    Same author

    Dose responses from inhaled monodisperse aerosols of 244Cm2O3 in the lung, liver and skeleton of F344 rats and comparison with 239PuO2.

    Radiation research·1997
    Same author

    Biological effects of 137CsCl injected in beagle dogs of different ages.

    Radiation research·1996
    Same author

    Classification of cystic keratinizing squamous lesions of the rat lung: report of a workshop.

    Toxicologic pathology·1996
    Same author

    The effect of 6-aminonicotinamide on testicular development in the rat.

    Veterinary and human toxicology·1996

    Area of Science:

    • Toxicology
    • Nephrology
    • Pharmacology

    Background:

    • Citrinin is a mycotoxin with known nephrotoxic potential.
    • Understanding its toxicity profile is crucial for risk assessment.

    Purpose of the Study:

    • To determine the lethal dose 50 (LD50) of citrinin in rabbits via oral and intraperitoneal routes.
    • To characterize the clinical signs and pathological alterations induced by citrinin exposure.

    Main Methods:

    • Three trials involving single or multiple doses of citrinin administered to rabbits.
    • Oral and intraperitoneal routes of administration were used.
    • LD50 determination, clinical sign observation, and histopathological examination of kidneys.

    Main Results:

    • The 72-hr LD50 was 50 mg/kg (intraperitoneal) and 134 mg/kg (oral).
    • Clinical signs included fluid diarrhea; pathological findings were primarily kidney damage (tubular degeneration and necrosis).
    • Earliest histopathological change was cytoplasmic vacuolation; tubular regeneration was observed by day 7.

    Conclusions:

    • Citrinin exhibits significant oral and intraperitoneal toxicity in rabbits.
    • The kidney is the primary target organ for citrinin-induced toxicity.
    • Both acute and repeated exposure to citrinin can cause renal tubular damage and regeneration.

    Related Experiment Videos