Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The fragile X: a scanning electron microscope study.

C J Harrison, E M Jack, T D Allen

    Journal of Medical Genetics
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Scanning electron microscopy (SEM) precisely located the fragile X chromosome site. This advanced technique confirmed light microscopy findings of an isochromatid gap at the fragile X site.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluating the precision of computer adaptive testing in longitudinal hand surgery analyses: A psychometric approach.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2025
    Same author

    Effectiveness of routine provision of feedback from patient-reported outcome measurements for cancer care improvement: a systematic review and meta-analysis.

    Journal of patient-reported outcomes·2023
    Same author

    Appraisal of International Guidelines for Cutaneous Melanoma Management using the AGREE II assessment tool.

    JPRAS open·2022
    Same author

    Construct validity of the anglicised FACE-Q skin cancer module.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2021
    Same author

    Automated conversational agents for post-intervention follow-up: a systematic review.

    BJS open·2021
    Same author

    Emergence of Parechovirus A4 Central Nervous System Infections among Infants in Kansas City, Missouri, USA.

    Journal of clinical microbiology·2019
    Same journal

    Longest surviving patient with a homozygous splice-altering <i>EGFR</i> pathogenic variant presenting with skin autoinflammation and a Bartter-like salt-losing tubulopathy.

    Journal of medical genetics·2026
    Same journal

    Functional characterisation and pathological significance of variants of <i>MEF2C</i> promoter in tetralogy of Fallot.

    Journal of medical genetics·2026
    Same journal

    Identification of biallelic loss-of-function <i>PREP</i> variants in three individuals with syndromic intellectual disability.

    Journal of medical genetics·2026
    Same journal

    Inherited retinal disease genes with dual inheritance patterns: insights from the IRD-PT registry.

    Journal of medical genetics·2026
    Same journal

    Interpreting <i>TP53</i> variants: somatic mosaicism and <i>ERCC6L2</i>-driven clonal evolution.

    Journal of medical genetics·2026
    Same journal

    Review of estimates of birth incidence and population prevalence over time and between countries of the rare neurodevelopmental condition Prader-Willi syndrome.

    Journal of medical genetics·2026
    See all related articles

    Area of Science:

    • Genetics
    • Microscopy

    Background:

    • Fragile X syndrome is a genetic disorder.
    • The fragile X chromosome has a characteristic fragile site.

    Purpose of the Study:

    • To investigate the fragile X chromosome using SEM.
    • To precisely locate the fragile site on the X chromosome.

    Main Methods:

    • Scanning electron microscopy (SEM) was employed.
    • Observations were compared with light microscopy (LM).

    Main Results:

    • SEM confirmed the fragile site as an isochromatid gap.
    • SEM provided a more precise localization of the fragile site to Xq27.3.

    Conclusions:

  • SEM offers enhanced visualization of chromosomal structures.
  • The precise location of the fragile site was determined using SEM.