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cis-Diamminedichloroplatinum: a cytostatic with an ototoxic effect
Abstract:
Among 74 patients treated with cis-diamminedichloroplatinum in total doses of 130-590 mg/m2 body surface area, high tone hearing loss was observed in 3. The caloric and rotatory responses were reduced in 3 other patients. Optokinetic responses remained normal in all patients.