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Torulopsis glabrata perinephric abscess
The Journal of Urology
|November 1, 1983
Abstract:
Torulopsis glabrata perinephric abscess has not been reported previously. The pathogenesis of the disease is by the ascending route, culminating in papillary necrosis and microabscesses that break into the perinephric space. Preoperative diagnosis is difficult and awareness of this entity is helpful. Treatment consists of surgery and systemic antifungal therapy. The recent antifungal agent, ketoconazole, is discussed.
Insights
A rare Torulopsis glabrata perinephric abscess, originating from an ascending route infection, presents diagnostic challenges. Early surgical and antifungal treatment, potentially including ketoconazole, is crucial for patient outcomes.
Area of Science:
- Nephrology
- Infectious Diseases
- Mycology
Background:
- Perinephric abscesses are serious kidney infections.
- Torulopsis glabrata is a yeast pathogen.
- This specific fungal abscess has not been previously documented.
Observation:
- The pathogenesis involves an ascending route infection.
- This leads to papillary necrosis and microabscess formation.
- These microabscesses extend into the perinephric space.
Findings:
- Preoperative diagnosis of this condition is challenging.
- Increased clinical awareness is essential for timely identification.
- Treatment requires a combination of surgical intervention and systemic antifungal therapy.
Implications:
- This study highlights a novel clinical presentation of Torulopsis glabrata infection.
- It emphasizes the need for considering fungal etiologies in complex perinephric abscesses.
- The discussion of ketoconazole suggests its potential role in managing such infections.