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Snuff dipper's carcinoma.

W F McGuirt

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Long-term snuff dipping is linked to oral and oropharyngeal cancers, primarily in older women. Cancers often occurred in the cheek or gum, with high recurrence rates and associated leukoplakia.

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    Area of Science:

    • Oral Oncology
    • Cancer Epidemiology
    • Head and Neck Pathology

    Background:

    • Snuff dipping is a recognized risk factor for oral cancers.
    • Understanding the specific patterns and outcomes of snuff-associated oral and oropharyngeal tumors is crucial for targeted prevention and treatment.

    Purpose of the Study:

    • To investigate the characteristics, locations, and treatment outcomes of oral and oropharyngeal tumors in patients who exclusively used snuff.
    • To assess the association between long-term snuff use and the development of concurrent or subsequent oral lesions like leukoplakia.

    Main Methods:

    • Retrospective analysis of 290 patients with primary oral cavity or oropharyngeal tumors.
    • Identification of 57 patients who exclusively used snuff as their carcinogenic agent.

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  • Clinical and histological examination of tumor sites, grading, and treatment modalities (irradiation or resection).

    • Main Results:

    • The study identified 57 exclusive snuff users, predominantly white women over 60 with over 40 years of use.
    • Carcinomas were most frequent in the buccal (47.5%) and alveolar (31.5%) regions, correlating with snuff placement.
    • Many tumors, clinically resembling verrucous carcinomas, were histologically well-differentiated squamous cell carcinomas. Treatment with irradiation or resection showed similar efficacy for comparable tumor grades.
    • A high rate of recurrence or contiguous second primary tumors (58%) was observed, with nearly half (47.3%) having concurrent leukoplakia.

    Conclusions:

    • Exclusive, long-term snuff dipping is associated with specific locations and types of oral and oropharyngeal squamous cell carcinomas.
    • The high incidence of recurrence and associated leukoplakia highlights the progressive, panmucosal effects of chronic snuff use.
    • Effective treatment strategies for these tumors are similar to other oral squamous cell carcinomas, but the underlying cause necessitates focused prevention efforts.