Domiodol; separation of cis and trans isomers and comparison of their pharmacological activity

Cis and trans isomers of 2-iodomethyl-4-hydroxymethyl-1,3-dioxolane (domiodol, MG 13 608) were separated by preparative GLC and prepared on a larger scale by previous resolution of an intermediate. Acute toxicity and effect on respiratory tract excretion were evaluated for domiodol and for each isomer: no significant differences were found.