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Related Experiment Videos

Autonomic neuropathy in leprosy.

M K Kyriakidis, C G Noutsis, C A Robinson-Kyriakidis

    International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
    |September 1, 1983
    PubMed
    Summary

    Leprosy patients show impaired autonomic nervous system control over their cardiovascular system. Both parasympathetic and sympathetic functions are affected, indicating widespread autonomic dysfunction in lepromatous leprosy.

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    Area of Science:

    • Cardiovascular physiology
    • Autonomic nervous system function
    • Neurology

    Background:

    • Leprosy, particularly the lepromatous form, can affect various organ systems.
    • Autonomic dysfunction is a potential complication of leprosy, but its extent is not fully characterized.
    • Cardiovascular reflexes are key indicators of autonomic nervous system integrity.

    Purpose of the Study:

    • To investigate the integrity of autonomic cardiovascular control in patients with lepromatous leprosy.
    • To assess the function of both parasympathetic and sympathetic branches of the autonomic nervous system in this patient group.

    Main Methods:

    • Utilized simple tests evaluating cardiovascular reflexes.
    • Compared autonomic function in 21 lepromatous leprosy patients against 10 healthy controls.

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    Main Results:

    • Demonstrated significant impairment in cardiovascular reflex responses in lepromatous leprosy patients.
    • Evidence of compromised parasympathetic function was observed.
    • Evidence of compromised sympathetic function was also observed.

    Conclusions:

    • Lepromatous leprosy is associated with impaired autonomic control of the cardiovascular system.
    • Both parasympathetic and sympathetic nervous system functions are demonstrably affected in these patients.
    • Autonomic neuropathy should be considered in the clinical management of lepromatous leprosy.