Related Experiment Videos
Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum
Research Communications in Chemical Pathology and Pharmacology
|October 1, 1983
Abstract:
Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.