Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Twin concordance for a binary trait. I. Statistical models illustrated with data on drinking status.

M C Hannah, J L Hopper, J D Mathews

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1983
    PubMed
    Summary

    This study introduces a flexible maximum likelihood method for analyzing twin data on binary traits. Results suggest higher concordance for drinking status in monozygous twins compared to dizygous twins.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Milk production of cows grazing pasture supplemented with grain mixes containing canola meal or corn grain or both over the first 100 days of lactation.

    Journal of dairy science·2024
    Same author

    Effect of forage type on swallowed bolus mass and a method for counting swallows in dairy cattle.

    Journal of dairy science·2023
    Same author

    A human donor (cadaveric) observation study of three needle placements in the piriformis muscle.

    The Journal of manual & manipulative therapy·2022
    Same author

    General resource for ionospheric transient investigations (GRITI): An open-source code developed in support of the Dinsmore et al. (2021) results.

    MethodsX·2021
    Same author

    Using estimated nutrient intake from pasture to formulate supplementary concentrate mixes for grazing dairy cows.

    Journal of dairy science·2021
    Same author

    An independent external validation of melanoma risk prediction models using the Australian Melanoma Family Study.

    The British journal of dermatology·2020

    Area of Science:

    • Biostatistics
    • Behavioral Genetics
    • Twin Studies

    Background:

    • Analyzing binary response data in twins presents statistical challenges.
    • Existing methods often rely on untestable distributional assumptions.
    • Efficiently utilizing twin data for genetic and environmental analyses is crucial.

    Purpose of the Study:

    • To introduce a flexible maximum likelihood method for binary twin data analysis.
    • To incorporate explanatory variables like age and sex into twin analyses.
    • To overcome the limitations of distributional assumptions in liability models.

    Main Methods:

    • Developed a novel statistical approach based on maximum likelihood theory.
    • Applied the method to analyze binary drinking status in adult twins.

    Related Experiment Videos

  • Accounted for potential biases in twin ascertainment, specifically for male dizygous twins.

    • Main Results:

    • The proposed method offers flexibility and efficient data utilization.
    • Preliminary analysis of drinking status in adult twins was performed.
    • Monozygous twins exhibited greater concordance for drinking status than dizygous twins, despite ascertainment biases.

    Conclusions:

    • The flexible maximum likelihood method provides a robust framework for twin data analysis.
    • Findings support a genetic component influencing drinking status concordance in twins.
    • Further research with refined ascertainment strategies is warranted.