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Related Experiment Videos

Behavioral responses to amphetamines in identical twins.

J C Crabbe, L F Jarvik, E H Liston

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1983
    PubMed
    Summary

    Genetic factors influence how individuals respond to amphetamines. This study found that identical twins showed similar behavioral and physiological reactions to amphetamine (a stimulant drug), suggesting a genetic basis for these responses.

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    Area of Science:

    • Psychopharmacology
    • Behavioral Genetics

    Background:

    • Individual differences in response to stimulant drugs like amphetamines are significant.
    • Understanding the genetic and environmental contributions to these responses is crucial for personalized medicine and drug development.

    Purpose of the Study:

    • To investigate the extent to which genetic factors mediate the behavioral and physiological effects of amphetamines.
    • To examine the concordance of responses to d-amphetamine and l-amphetamine in monozygotic twins.

    Main Methods:

    • Six pairs of male monozygotic twins were administered d-amphetamine, l-amphetamine, or placebo in a repeated-measures design.
    • Cognitive, psychomotor, personality, mood, and pain variables were assessed.
    • Plasma levels of amphetamine isomers were measured.

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    Main Results:

    • Twin pairs exhibited similar responses to placebo, indicating genetic influence on baseline behaviors.
    • Cotwins showed similar reactions to amphetamine on cognitive tests, mood, and personality variables (e.g., hostility, tension).
    • Similar plasma levels of amphetamine isomers were observed between cotwins.

    Conclusions:

    • The findings suggest that genetic factors play a role in mediating various behavioral effects of amphetamines.
    • While shared environmental influences cannot be excluded, the results strongly support genetic mediation of amphetamine's impact on cognition, mood, and personality.