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Published on: March 13, 2012
Central nervous system supersensitivity and withdrawal from long-term diphenylhydantoin treatment
Abstract:
The effects of withdrawal from long-term treatment with increasing doses of diphenylhydantoin (DPH) were studied in rats. The dose of DPH was increased from 5 to 200 mg/kg over 20 days and the animals were tested 72 h after withdrawal. DPH withdrawal induced a leftward displacement of the dose-response curves obtained for the convulsive effects of both picrotoxin and metrazol and decreased the latency of 3-mercaptopropionic acid-induced seizures. These effects were interpreted to be a consequence of supersensitivity of the central nervous system induced by long-term DPH depression.
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