Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity04:20

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity

1.4K
Here, we show the procedures for FAM83A knockdown; the assays to detect its effects on proliferation, migration, and invasion of cervical cancer cells; and the sensitization of these cells to cisplatin. This study provides a promising target gene for cervical cancer and a reference for further drug...
1.4K
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish13:25

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

6.5K
This protocol describes the procedures to induce Acute Kidney Injury (AKI) in adult zebrafish using cisplatin as a nephrotoxic agent. We detailed the steps to evaluate the reproducibility of the technique and two techniques to analyze inflammation and cell death in the renal tissue, flow cytometry and TUNEL,...
6.5K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

10.9K
The management of isolated recurrent lung cancer in a previously-irradiated field is challenging. Here, we describe an endobronchial ultrasound (EBUS)-guided cisplatin injection for the management of patients with localized lung cancer recurrence in a previously-radiated field.
10.9K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

12.5K
Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.
12.5K
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

9.5K
AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor...
9.5K
Induced-fit Model01:13

Induced-fit Model

88.9K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
88.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating cytokines in patients undergoing tonsillectomy with fibrin glue.

International journal of pediatric otorhinolaryngology·2012
Same author

Urinary tract infections caused by multi-drug resistant Proteus mirabilis: Risk factors and clinical outcomes.

Infection·2009
Same author

Clinical/otologic score before and during treatment of acute otitis media.

Acta paediatrica (Oslo, Norway : 1992)·2007
Same author

Impact of 4% chlorhexidine whole-body washing on multidrug-resistant Acinetobacter baumannii skin colonisation among patients in a medical intensive care unit.

The Journal of hospital infection·2007
Same author

Characteristics of low-risk patients hospitalized with community-acquired pneumonia.

European journal of internal medicine·2007
Same author

Conservative management of implantable cardioverter defibrillator-related endocarditis due to Bacillus spp.

Infection·2007

Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

1.4K

Cisplatin-induced bradycardia.

F Schlaeffer, F Tovi, A Leiberman

    Drug Intelligence & Clinical Pharmacy
    |December 1, 1983
    PubMed
    Summary

    Cisplatin chemotherapy can cause bradycardia (slow heart rate), a previously unreported side effect. This cardiac toxicity may result from cisplatin depositing in the heart's natural pacemaker.

    Area of Science:

    • Cardiology
    • Oncology
    • Pharmacology

    Background:

    • Cisplatin is a widely used chemotherapy agent for various cancers.
    • Cardiotoxicity is a known side effect of cisplatin, but bradycardia has not been previously documented.

    Observation:

    • A patient undergoing cisplatin therapy experienced recurrent episodes of bradycardia.
    • The patient's heart rate normalized after discontinuation of cisplatin.

    Findings:

    • This case report describes the first instance of cisplatin-induced bradycardia.
    • The mechanism may involve cisplatin deposition in the sinoatrial node, affecting heart rhythm.

    Implications:

    • Clinicians should monitor for bradycardia in patients receiving cisplatin.

    More Related Videos

    Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
    13:25

    Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

    Published on: May 15, 2021

    6.5K
    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
    04:04

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

    Published on: February 12, 2017

    10.9K

    Related Experiment Videos

    Last Updated: Jan 20, 2026

    Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
    04:20

    Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

    Published on: February 9, 2024

    1.4K
    Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
    13:25

    Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

    Published on: May 15, 2021

    6.5K
    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
    04:04

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

    Published on: February 12, 2017

    10.9K
  • Further research is warranted to elucidate the mechanism of cisplatin-induced bradycardia and its management.