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Summary
Atropine toxicity in twins caused systemic effects like fever and rapid heart rate. Physostigmine successfully treated the toxicity, highlighting the importance of careful atropine dosage instructions.
Area of Science:
- Toxicology
- Pharmacology
- Pediatrics
Background:
- Atropine, an anticholinergic medication, is used for various medical purposes, including ophthalmic applications.
- Systemic toxicity can occur with improper dosing or accidental ingestion, particularly in children.
Observation:
- Two cases of monozygotic twins presented with severe systemic atropine toxicity.
- Manifestations included hyperpyrexia, agitation, mydriasis, tachypnea, tachycardia, decreased gastrointestinal motility, anhydrosis, and skin flush.
Findings:
- Intravenous physostigmine was administered as the treatment of choice.
- Physostigmine effectively resolved the toxic crisis by counteracting atropine's anticholinergic effects.
Implications:
- Physostigmine is a crucial antidote for atropine toxicity.
- Parental education on correct atropine dosage and recognition of systemic toxicity signs is vital to prevent adverse events, especially with ophthalmic use.