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Pharmacological studies of a series of dermorphin related tetrapeptides
Arzneimittel-Forschung
|January 1, 1983
Abstract:
The activity pattern of 8 dermorphin related tetrapeptides was determined in guinea-pig ileum and mouse vas deferens bioassays. Naloxone was a powerful antagonist of all compounds in both preparations. Moreover the biological activities of the test compounds were correlated in a statistically significant way to the lipophilic character of the C-terminal substituents.