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Apical hypertrophic cardiomyopathy: clinical and metabolic studies

M E Bertrand, P Y Tilmant, J M Lablanche

    European Heart Journal
    |November 1, 1983
    PubMed

    Insights

    This study describes concentric apical hypertrophy, a type of hypertrophic cardiomyopathy. Patients showed characteristic ECG and echocardiogram findings, with some developing diffuse disease over time.

    Area of Science:

    • Cardiology
    • Cardiovascular Diseases
    • Internal Medicine

    Background:

    • Hypertrophic cardiomyopathy encompasses various forms, including non-obstructive types.
    • A specific subset presents with concentric apical hypertrophy, characterized by distinct electrocardiogram (ECG) findings.

    Purpose of the Study:

    • To characterize patients with concentric apical hypertrophy.
    • To investigate the clinical presentation, diagnostic findings, and potential progression of this cardiomyopathy.

    Main Methods:

    • Study included seven patients with giant negative T waves and concentric apical hypertrophy.
    • Diagnostic tools included heart catheterization, M-mode and 2D echocardiography, and coronary angiography.
    • Myocardial metabolism was assessed using atrial pacing and lactate sampling in some patients.

    Main Results:

    • No outflow tract obstruction was found; coronary angiography was normal.
    • Ventriculography revealed a spade-like apical configuration with significantly increased apical wall thickness.
    • Myocardial metabolism abnormalities were detected in five patients; follow-up showed progression in some.

    Conclusions:

    • Concentric apical hypertrophy is a distinct entity within hypertrophic cardiomyopathies.
    • This condition may progress to diffuse hypertrophic cardiomyopathy, indicated by increased wall thickness over time.
    • Further research is needed to understand the long-term prognosis and management.

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