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Related Experiment Videos

Cinnamic aldehyde: a survey of consumer patch-test sensitization.

P J Danneman, K A Booman, J Dorsky

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Cinnamic aldehyde in consumer products is unlikely to cause allergic reactions. While it can cause reactions when tested alone, extensive patch testing shows a very low potential for hypersensitivity in the general population.

    Area of Science:

    • Dermatology
    • Toxicology
    • Cosmetic Science

    Background:

    • Cinnamic aldehyde is a common ingredient in fragrances and flavors.
    • Contact hypersensitivity is a significant concern for consumer products.

    Purpose of the Study:

    • To evaluate the potential of cinnamic aldehyde to induce or elicit delayed contact hypersensitivity.
    • To assess the safety of cinnamic aldehyde in consumer products based on patch test data.

    Main Methods:

    • Analysis of 4117 patch test results from consumer products and fragrance blends containing cinnamic aldehyde.
    • Testing of cinnamic aldehyde alone and in mixtures across various concentrations.

    Main Results:

    • Cinnamic aldehyde in products up to 6 X 10(-1)% showed no detectable hypersensitivity potential.

    Related Experiment Videos

  • Patch testing with cinnamic aldehyde alone induced a dose-related response.
  • No pre-existing hypersensitivity reactions were observed in the general population across 4117 tests.

    • Conclusions:

    • Cinnamic aldehyde has a very low potential to induce or elicit hypersensitivity in the general population at typical consumer product concentrations.
    • The risk of cinnamic aldehyde causing allergic reactions is minimal in standard use.