Consequences of decreased brain serotonin in the pyridoxine-deficient young rat

The concentrations of serotonin in various brain areas were significantly decreased in the pyridoxine-deficient young rat. There was no change in the concentration of dopamine. Both Bmax and Kd of [3H]serotonin binding to membrane preparations from cerebral cortex were increased in deficiency and were restored to normal upon pyridoxine supplementation. There was no change in [3H]spiroperidol binding to corpus striatal membrane preparations in pyridoxine-deficient rats.