The effects of beta-phenylethylamine and phenylethanolamine on water intake in rats: a temporal analysis

Male Wistar rats were adapted to a restricted access schedule of water intake. For each animal overall water intake (ml) and number of licks per minute were measured over the period of access to water. The effects of various doses of beta-phenylethylamine and of phenylethanolamine were assessed in separate groups of animals. In terms of effects on overall consumption the two amines were equipotent in suppressing water intake. The local analysis revealed, however, that beta-phenylethylamine was more potent, but had a much shorter duration of action than phenylethanolamine.