[Effect of ciclotropium bromide on pressure in the human common bile duct]

The effect of a new anticholinergic drug, ciclotropium bromide, on artificially induced pressure elevations in the common bile duct is reported. The endoscopic manometry allows a precise pressure measurement in the biliary system. For the artificial pressure elevation an X-ray contrast medium was injected into the common bile duct until the pain threshold was reached. In each patient a statistically significant pressure reduction accompanied by pain relief was reached. The method used shows the drug effects by objective measurement of the pressure reduction and the subjective indication of the pain relief.