Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differentiation, ageing, and terminal differentiation: a semantic analysis.

J M Reiner

    Journal of Theoretical Biology
    |December 21, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anaerobic glycolysis in nervous tissue.

    The Journal of biological chemistry·2010
    Same author

    Comparison of the mechanisms whereby NaN3 and 2-4-dinitrophenol suppress anaerobic carbohydrate assimilation.

    Federation proceedings·2010
    Same author

    Adaptation to a substrate in the absence of its utilization.

    Federation proceedings·2010
    Same author

    The effect of age on the carbohydrate metabolism of tissue homogenates.

    Journal of gerontology·2010
    Same author

    Effect of enzyme inhibitors on transformation of enzymes in the living cell.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
    Same author

    The theory of isotope dilution.

    Archives of biochemistry·2010
    Same journal

    Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

    Journal of theoretical biology·2026
    Same journal

    The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

    Journal of theoretical biology·2026
    Same journal

    Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

    Journal of theoretical biology·2026
    Same journal

    An integrative model of FGF2-induced signaling and muscle cell proliferation.

    Journal of theoretical biology·2026
    Same journal

    A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

    Journal of theoretical biology·2026
    Same journal

    Integrated tick management strategies in fragmented peridomestic environments.

    Journal of theoretical biology·2026
    See all related articles

    Semantic clarity is crucial for solving theoretical problems in cell differentiation and aging. Addressing linguistic ambiguities and adopting operational views are key to advancing molecular biology research.

    Area of Science:

    • Cellular Biology
    • Molecular Biology
    • Gerontology

    Background:

    • Theoretical analysis of cell differentiation and aging faces significant linguistic and semantic challenges.
    • Ambiguous terminology and metaphorical language, such as "terminal differentiation" and "commitment," hinder clear scientific understanding.

    Purpose of the Study:

    • To critically examine the semantic difficulties in the theoretical analysis of cell differentiation and aging.
    • To review experimental evidence and proposed models for "terminal differentiation" and "clonal senescence."
    • To propose a molecular model that addresses existing objections and semantic issues.

    Main Methods:

    • Review of critical experiments on "terminal differentiation" and "clonal senescence."
    • Analysis of proposed theoretical models, including a novel molecular model.

    Related Experiment Videos

  • Examination of semantic ambiguities and the need for operational definitions in cell biology.

    • Main Results:

    • Identified semantic ambiguities as a major obstacle in understanding cell differentiation and aging.
    • Reviewed experimental data related to "terminal differentiation" and "clonal senescence."
    • Proposed a molecular model for aging that aims to overcome limitations of previous models.

    Conclusions:

    • Resolving semantic issues and adopting empirical, operational viewpoints are essential for theoretical progress.
    • Molecular biology offers powerful tools, but requires critical semantic clarity for complete analysis.
    • Understanding the precise problem definition is paramount for scientific advancement in cell biology and aging research.