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Updated: Aug 18, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Activation of lipid peroxidation: a mechanism triggering the autoimmune response
Abstract:
Emotional-pain stress leads to accumulation of lipid peroxidation products in rat brain tissues and to an increase in the number of antibrain antibodies against water-soluble and membrane-bound antigens in rat blood. An injection of the free radical scavenger, 4-methyl-2.6-di-tert-butylphenol to experimental animals eliminates the accumulation of lipid peroxidation products "in vivo" and completely prevents the appearance of antibrain antibodies. The activation of lipid peroxidation under stress may be regarded as a possible cause of the brain-specific antibodies release into the blood flow.
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