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A crossover comparative study with two bulk laxatives
The Journal of International Medical Research
|January 1, 1983
Summary
Two bulk laxatives, Agiolax and Lunelax comp., effectively treated severe constipation in elderly patients over two weeks. Both senna-based preparations demonstrated good efficacy and safety without adverse effects.
Area of Science:
- Gastroenterology
- Geriatrics
- Pharmacology
Background:
- Severe constipation is a common issue in elderly patients.
- Bulk laxatives are frequently used for managing constipation.
Purpose of the Study:
- To compare the efficacy and safety of two bulk laxatives in elderly patients with severe constipation.
- To evaluate a new bulk laxative preparation (Agiolax) against an established one (Lunelax comp.).
Main Methods:
- A randomized, two-treatment, crossover study design was employed.
- Twenty elderly inpatients with severe constipation participated.
- Patients received one of two bulk laxatives daily for two weeks, followed by the other preparation.
Main Results:
- Both Agiolax (15 mg senna glucosides) and Lunelax comp. (25 mg senna glucoside A + B) showed effective treatment for severe constipation.
- No significant side-effects were observed with either preparation during the study period.
Conclusions:
- Agiolax and Lunelax comp. are both effective and well-tolerated bulk laxatives for managing severe constipation in the elderly.
- The senna content differs between the preparations, but both yield comparable positive outcomes.