Related Experiment Video
Updated: Aug 8, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
Published on: November 18, 2009
The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase
Abstract:
The nucleotide sequence of the human dihydrofolic acid reductase (DHFR) reading frame has been derived from the analysis of human DHFR cDNA. This sequence and the corresponding amino acid sequence have been compared with those available for the enzyme and its coding segment from other organisms. There is an 89% nucleotide sequence homology between the human DHFR reading frame and the mouse coding sequence. Furthermore, amino acid-sequence homologies of 74%, 81% and 89% has been found between human DHFR and chicken, bovine and mouse DHFR, respectively.
Related Concept Videos
The Central Dogma
Cell Specific Gene Expression
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Role of Reduced Coenzymes NADH and FADH₂
The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...

