Related Experiment Video
Updated: May 11, 2026

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
Published on: October 13, 2015
Yersinia enterocolitica pharyngitis
Abstract:
During the investigation of a large multistate outbreak of milk-borne yersiniosis, 14 patients who presented with pharyngitis had Yersinia enterocolitica isolated from the throat. Their illness was characterized by sore throat and fever without enteritis; 3 needed hospitalization. All patients tested had leukocytosis and an elevated convalescent-phase serum titer against the outbreak strain. In contrast to patients with enteritis, who were children, all patients with pharyngitis were adults. Thus, Y. enterocolitica may be responsible for some sporadic cases of pharyngitis in which the throat culture is negative for other pathogens.
Insights
Yersinia enterocolitica, a bacterium, can cause pharyngitis (sore throat) in adults, particularly during outbreaks. This finding suggests it may be an overlooked cause of sporadic pharyngitis when other pathogens are absent.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Yersinia enterocolitica is a known cause of gastroenteritis, primarily in children.
- Milk-borne outbreaks of yersiniosis have been documented previously.
- Pharyngitis is typically associated with viral or streptococcal infections.
Observation:
- During a multistate milk-borne outbreak, 14 adult patients presented with pharyngitis and fever, but no enteritis.
- Yersinia enterocolitica was isolated from the throat cultures of these patients.
- Patients exhibited leukocytosis and elevated serum titers against the outbreak strain.
Findings:
- Yersinia enterocolitica can manifest as pharyngitis in adults, distinct from its typical gastrointestinal presentation.
- Adult patients with Y. enterocolitica pharyngitis often present with sore throat and fever, requiring hospitalization in some cases.
- This bacterial infection may be a cause of sporadic pharyngitis, especially when routine throat cultures are negative for common pathogens.
Implications:
- Clinicians should consider Yersinia enterocolitica in the differential diagnosis of adult pharyngitis, particularly in outbreak settings or when other causes are ruled out.
- This expands the known clinical spectrum of Yersinia enterocolitica infections.
- Further research is warranted to understand the pathogenesis of Y. enterocolitica-induced pharyngitis and its prevalence in sporadic cases.
Related Concept Videos
Lysogenic Cycle of Bacteriophages
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Stringent Response in E. coli
Bacterial Phylum Spirochaetes
Bacterial Gastroenteritis

