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Systemic blastomycosis in children.

R W Steele, R S Abernathy

    Pediatric Infectious Disease
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Systemic blastomycosis in children, a fungal infection, affects males and Black children more often. Early antifungal treatment, typically with amphotericin B, is crucial for survival and preventing chronic lung disease.

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    Area of Science:

    • Mycology
    • Pediatric Infectious Diseases
    • Public Health Epidemiology

    Background:

    • Blastomycosis is a systemic fungal infection caused by Blastomyces dermatitidis.
    • Pediatric cases of blastomycosis are relatively rare, requiring specific clinical and epidemiological understanding.
    • Arkansas has endemic regions for blastomycosis, necessitating awareness in pediatric populations.

    Purpose of the Study:

    • To review pediatric cases of systemic blastomycosis in Arkansas.
    • To identify epidemiological patterns and demographic predispositions in childhood blastomycosis.
    • To assess outcomes and treatment efficacy in pediatric patients.

    Main Methods:

    • Retrospective review of ten pediatric cases of systemic blastomycosis.
    • Analysis of patient demographics, affected organ systems, and treatment regimens.

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  • Evaluation of case fatality rates and long-term outcomes.

    • Main Results:

    • No specific age predisposition was observed in childhood blastomycosis.
    • A higher incidence was noted in males (60%) and Black children (80%).
    • Commonly affected organ systems included pulmonary, skeletal, and skin.

    Conclusions:

    • Systemic blastomycosis in children requires prompt diagnosis and treatment.
    • Amphotericin B remains a primary therapeutic agent with a case fatality rate below 10%.
    • Early antifungal intervention is key to survival and preventing chronic pulmonary complications.