Glycosaminoglycans of solid and ascites forms of the P1798 murine lymphosarcoma

Total glycosaminoglycan levels are similar from subcutaneous, ascites and mesenteric forms of the P1798 lymphosarcoma. However, P1798 cells implanted subcutaneously produce a solid tumor rich in hyaluronic acid with lesser amounts of chondroitin 4-/6-sulfates as well as an undersulfated species of chondroitin sulfate, while cells implanted intraperitoneally produce ascites tumors which generate hyaluronic acid, almost exclusively. Mice bearing advanced ascites tumors develop solid mesenteric tumors which exhibit chondroitin 4-/6-sulfates and under-sulfated chondroitin sulfate in addition to hyaluronic acid.