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Updated: Aug 5, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[The effect of the polymeric quaternary ammonium salt,2,5-ionene on blood coagulation]
Abstract:
In modelling overdosages of the polymeric antagonist in cases of heparin neutralization the effect of 2.5-ionene on the blood coagulation in rabbits was considered during investigations in vivo. It is shown that even appreciable overdosages of 2.5-ionene are not attended by the effect of hypocoagulation. Shortening the plasma coagulation time according to the thromboplastic activity after Quick occurs through activation of the factor X proceeding against the background of falling activity of some other coagulation factors and comes as a result of excess 2.5-ionene in the blood. A reduced amount and lowering of the aggregation capacity of the thrombocytes are noted.
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