Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function and bone turnover.

J W Bijlsma, S A Duursma, J M Roelofs

    Acta Endocrinologica
    |September 1, 1983
    PubMed
    Summary

    Thyroid hormones directly impact bone turnover. Thyrotoxicosis decreases bone turnover markers, while hypothyroidism increases them, suggesting a direct hormonal effect on bone metabolism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Can adverse effects of glucocorticoid therapy be prevented and treated?

    Expert opinion on pharmacotherapy·2016
    Same author

    The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids.

    Osteoarthritis and cartilage·2016
    Same author

    Response to Dr Forestier's eLetter on EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis.

    Annals of the rheumatic diseases·2013
    Same author

    European League Against Rheumatism recommendations for the inclusion of patient representatives in scientific projects.

    Annals of the rheumatic diseases·2011
    Same author

    EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis.

    Annals of the rheumatic diseases·2009
    Same author

    EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT.

    Annals of the rheumatic diseases·2008

    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Mineral Metabolism

    Background:

    • Thyroid hormones play a crucial role in regulating various physiological processes, including bone metabolism.
    • The precise mechanisms by which thyroid dysfunction affects bone turnover are not fully elucidated.
    • Understanding these mechanisms is vital for managing bone health in patients with thyroid disorders.

    Purpose of the Study:

    • To investigate the direct effects of thyroid hormones on bone turnover.
    • To compare bone turnover parameters in patients with thyrotoxicosis and hypothyroidism versus their euthyroid states.
    • To explore the potential involvement of calcium-regulating hormones and growth hormone.

    Main Methods:

    • Studied 15 thyrotoxic and 14 hypothyroid patients.
    • Assessed bone turnover parameters (serum calcium, phosphatases, urinary calcium/creatinine, hydroxyproline/creatinine) in both diseased and euthyroid states.
    • Measured levels of parathyroid hormone, calcitonin, vitamin D metabolites, and growth hormone.

    Main Results:

    • Thyrotoxicosis reversal to euthyroid state decreased bone turnover markers (serum calcium, acid and alkaline phosphatase, urinary calcium/creatinine, hydroxyproline/creatinine).
    • Hypothyroidism reversal to euthyroid state increased bone turnover markers (serum calcium, alkaline phosphatase, urinary hydroxyproline/creatinine).
    • No significant changes in parathyroid hormone, calcitonin, or vitamin D metabolites were observed in hyperthyroid patients. Hypothyroid patients showed decreased 1.25-dihydroxyvitamin D and growth hormone levels upon becoming euthyroid.

    Conclusions:

    • Findings support a direct effect of thyroid hormones on bone turnover, particularly evident in thyrotoxicosis.
    • Somatomedin may also contribute to altered bone turnover in both hyperthyroidism and hypothyroidism.
    • Thyroid hormone status significantly influences bone metabolism, independent of major calcium-regulating hormones.

    Related Experiment Videos