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Pilot study on the absolute and relative bioavailability of Synthroid and Levothroid, two brands of sodium
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|August 1, 1983
Abstract:
The absolute and relative bioavailability of levothyroxine was determined in young, healthy male subjects after administration of i.v. solution, p.o. solution, or one of two brand-name, commercially available tablets. The mean dose size was about 0.18 mg. Serum concentration-time data were obtained over a period of 50 h. The absolute bioavailabilities of the two tablet preparations were 66% and 72%, respectively.