Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iterative least-squares fitting programs in pharmacokinetics for a programmable handheld calculator.

A Messori, G Donati-Cori, E Tendi

    American Journal of Hospital Pharmacy
    |October 1, 1983
    PubMed
    Summary

    This study presents calculator programs for pharmacokinetic modeling. These programs efficiently estimate key variables for one-compartment oral and two-compartment intravenous models using nonlinear least-squares fitting.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatments for relapsed-refractory diffuse large B-cell lymphoma: comparison of overall survival outcomes observed with four novel agents.

    European review for medical and pharmacological sciences·2022
    Same author

    Restricted mean survival time in advanced non-small cell lung cancer treated with immune checkpoint inhibitors.

    European review for medical and pharmacological sciences·2021
    Same author

    Incidence of low-titre factor VIII inhibitors in patients with haemophilia A: meta-analysis of observational studies.

    Haemophilia : the official journal of the World Federation of Hemophilia·2017
    Same author

    Meta-Analysis: Limits and Benefits.

    Clinical drug investigation·2016
    Same author

    Effectiveness of Immunoglobulins for the Prevention of Systemic Infections : A Meta-Analysis of 8 Clinical Studies in Premature Infants.

    Clinical drug investigation·2016
    Same author

    Gastrointestinal and renal side effects of bisphosphonates: differentiating between no proof of difference and proof of no difference.

    Journal of endocrinological investigation·2014

    Area of Science:

    • Pharmacokinetics and computational modeling

    Background:

    • Pharmacokinetic (PK) models are crucial for understanding drug behavior in the body.
    • Accurate estimation of PK variables requires robust fitting methods.
    • Limited accessibility to sophisticated computational tools can hinder PK analysis.

    Purpose of the Study:

    • To develop and describe user-friendly software for pharmacokinetic model fitting.
    • To enable estimation of key variables for one-compartment oral and two-compartment intravenous models.
    • To provide an accessible and inexpensive tool for pharmacokinetic analysis.

    Main Methods:

    • Nonlinear least-squares fitting algorithms, specifically the Gauss-Newton method modified by Hartley.
    • Method of residuals for initial parameter estimation.
    • Implementation on a Hewlett-Packard HP-41 CV programmable calculator with extended memory modules.

    Related Experiment Videos

  • Inclusion of a lag-time estimation routine for oral models.

    • Main Results:

    • Successfully developed programs for fitting one-compartment oral and two-compartment intravenous PK models.
    • Demonstrated clinical applicability using previously published data.
    • Provided programming steps and user instructions for practical implementation.
    • Achieved efficient and cost-effective estimation of pharmacokinetic variables.

    Conclusions:

    • The developed calculator programs offer an efficient and inexpensive method for estimating pharmacokinetic variables.
    • These programs enhance the accessibility of PK analysis for researchers with limited resources.
    • The use of a modified Gauss-Newton algorithm minimizes convergence issues in the fitting process.