Tuning characteristics of cochlear nucleus units in response to electrical stimulation of the cochlea

The responses of single units in the ventral cochlear nucleus of acute anesthetized guinea pigs were studied with continuous sinusoidal electrical stimuli presented through a multi-electrode implant in the scala tympani. Implants had two or four electrodes along the axis of the scala with 1 mm separations. Best frequencies were consistently in the 100 Hz range (50-250 Hz) with thresholds of about 0.063 mA peak-to-peak. Tuning curves were usually symmetrical with slopes of 3-4 dB/octave, both below and above the best frequency. The relative sharpness of the tuning curves, as measured by Q10dB, averaged 0.2. Dynamic ranges as determined by the intensity-rate functions for the various frequencies were 2-15 dB. No significant difference was found between tuning characteristics of units in response to stimulation via the apical or basal pair of implant electrodes. The findings suggest some limitations on the applicability of independent stimulating channels in multi-electrode implants.